UROP Research Mentor Project Submission Portal: Submission #686 | Center for Undergraduate Research and Academic Engagement

Submission information

Submission Number: 686

Submission ID: 14051

Submission UUID: b38027bc-04e7-43b8-945a-0e2d3e6c2101

Submission URI: /urop-research-mentor-project-submission-portal

Submission Update: /urop-research-mentor-project-submission-portal?token=5VM-AcWZ7wgOGzndZxgq17ib42doiVpCqkX5WbfOFjo

Created: Fri, 07/19/2024 - 03:40 PM

Completed: Fri, 07/19/2024 - 04:40 PM

Changed: Thu, 09/12/2024 - 12:29 PM

Remote IP address: 128.186.175.157

Submitted by: Anonymous

Language: English

Is draft: No

Webform: UROP Project Proposal Portal

Submitted to: UROP Research Mentor Project Submission Portal

Research Mentor Information

Primary Research Mentor Name Yanchang Wang

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Contact Email (FSU Email if affiliated) yanchang.wang@med.fsu.edu

Position Title Faculty

FSU College (if applicable) Medicine

FSU Department or Non-FSU Organization Affiliation Biomedical Sciences

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Additional Research Mentor(s)

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Overall Project Details

Title of the Project A new mechanism that controls protein subcellular localization and function

Project Keywords protein SUMOylation, polySUMOylation, cell cycle, protein misfolding

Are you currently looking for research assistants? No

Number of Research Assistants Needed 2

Relevant Research Assistant Major(s) Biology, Biochemistry

Project Location: On FSU Main Campus

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Please select the choice that most accurately describes your expectations for the research assistant(s): In-person

Approximately how many hours a week would the research assistant(s) need to work? 10

Roughly what time frame do you expect research assistant(s) to work? During business hours

Overall Research Project Description Protein subcellualr localization is critical for its cellular function. Recently, our lab uncovered a new mechanism that controls protein subcellular localization through SUMOylation, a process in which SUMO proteins are covalently attached to specific lysine residues in target proteins. SUMOylation is important for stress response, cell cycle, DNA damage repair, and other cellular processes. SUMOylation imbalances can cause cancer and neurodegenerative diseases. The current focus of our lab is to understand how SUMOylation regulates the subcellular localization of key mitotic players and how SUMOylation is regulated during cell cycle.

Research Tasks Yeast strain construction
Molecular method to detect protein expression and modification
Cell imaging

Skills that research assistant(s) may need: Cell culture, microscopy

Mentoring Philosophy As an educator, I will enable students to learn some basic technology in genetics and cell biology by performing experiments, to receive training in critical thinking through the interaction with mentor and other lab members, to improve communication skills by presenting his/her own research work.

Please provide a link to your publications, a video clip, or a website for your research project (if applicable): https://www.sciencedirect.com/science/article/pii/S2211124724008210?via%3Dihub

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Are you interested in participating in the UROP Research Mentor Roundtable? Yes

Roundtable times and Zoom links Roundtable times and Zoom link: Friday, September 6, 2:00-3:00pm. This is drop-in style.
https://fsu.zoom.us/j/92708842643

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UROP Program Elements

Mentor Handbook, FAQs, and Communication Yes

UROP Performance Evaluation Yes

Materials Grant Yes

UROP Poster Presentation Yes

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Year 2024

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