UROP Research Mentor Project Submission Portal: Submission #1302

Submission information
Submission Number: 1302
Submission ID: 21106
Submission UUID: 861b6577-ef7d-41d5-8533-c2722219269c

Created: Wed, 08/20/2025 - 06:12 PM
Completed: Wed, 08/20/2025 - 06:12 PM
Changed: Mon, 08/25/2025 - 11:28 AM

Remote IP address: 144.174.212.88
Submitted by: Anonymous
Language: English

Is draft: No
Primary Research Mentor Name Kislay Parvatiyar
Research Mentor Preferred Pronouns He/Him
When potential research assistants are reaching out via email, what is your preferred honorific? Dr.
Contact Email (FSU Email if affiliated) kparvatiyar@fsu.edu
Position Title Faculty
FSU College (if applicable) Education, Health, and Human Sciences
FSU Department or Non-FSU Organization Affiliation Health, Nutrition, and Food Sciences
Headshot (optional)
Research Assistant Supervisor (if different from above)
Research Assistant Supervisor Preferred Pronouns
Research Assistant Supervisor Preferred Honorific?
Contact Email (FSU Email if affiliated)
Name of Other Faculty/Collaborator(s) (if applicable)
Other Faculty/Collaborator(s) Preferred Pronouns
Other Faculty/Collaborator(s) Preferred Honorific?
Contact Email (FSU Email if affiliated)
Title of the Project Investigating the innate immune response to bacterial quorum sensing molecules
Project Keywords innate immunity; pattern recognition receptors; host defense
Are you currently looking for research assistants? Yes
Number of Research Assistants Needed 2
Relevant Research Assistant Major(s) Biological sciences, Biochemistry, Health Sciences, etc
Project Location: On FSU Main Campus
If the project location is off campus, does the research assistant(s) need to provide their own transportation? Project is on FSU main campus
Please select the choice that most accurately describes your expectations for the research assistant(s): In-person
Approximately how many hours a week would the research assistant(s) need to work? 9-10
Roughly what time frame do you expect research assistant(s) to work? Flexible schedule (Combination of business and outside of business. TBD between student and research mentor.)
Overall Research Project Description Understanding how pathogen associated molecular patterns (PAMPs) modulate the host innate immune response provides important insight into infectious disease pathogenesis and other chronic inflammatory conditions. The bacterial molecule N-(3-oxo-dodecanoyl)-L-homoserine lactone (C12) is produced by the opportunistic pathogen Pseudomonas aeruginosa and has been well characterized for its role in quorum sensing and regulation of bacterial metabolism and motility. Its effects on host immunity are not well understood.
Our preliminary data implicates C12 as a mediator of mitochondrial dysfunction in multiple cell types. We observed that C12 can induce the expression of type-I interferons in mammalian macrophage cells. This induction is apparently dependent on STING, a critical signaling component of the cytosolic DNA sensing pathway. We will attempt to further characterize the mechanisms by which C12 activates type-I interferons in a STING dependent manner.
Research Tasks Biochemical and immunological benchwork including cell culture, quantitative real-time PCR, SDS PAGE, immunoblot, data analysis.
Skills that research assistant(s) may need: Ideal applicants will have successfully completed an introductory biology and chemistry course.
Mentoring Philosophy Teaching and mentorship has always been a rewarding experience throughout my academic career. The cornerstone of my teaching philosophy is that fundamental biological principles must be understood and not memorized, a notion that needs to be instilled in the classroom and in the laboratory. Concepts learned in lectures, seminars and meetings need to be reinforced in small, interactive group activities that include journal clubs, round-table discussions and lab meetings. Furthermore, the process of discovery is as vital to learning science as it is to research. Students who are given the opportunity to make scientific discoveries and contributions are more motivated and engaged, and develop critical thinking skills that are invaluable in scientific research. As a teacher and mentor, I’ve facilitated student learning and discovery through an emphasis on scientific reasoning, group problem solving, and assessing scientific data. I’ve also recognized that not all students learn in the same manner. As such, I’ve utilized one-on-one, personalized approaches to scientific education, focusing on the individual strengths of students to further encourage and develop their scientific endeavors.
Please provide a link to your publications, a video clip, or a website for your research project (if applicable): https://pubmed.ncbi.nlm.nih.gov/?term=parvatiyar+k&sort=date
Please add any additional information here (if applicable): Please reach out if you have interests in immunology, aging, and/or signal transduction research.
Are you interested in participating in the UROP Research Mentor Roundtable? No
Roundtable times and Zoom links
Mentor Handbook, FAQs, and Communication Yes
UROP Performance Evaluation Yes
Materials Grant Yes
UROP Poster Presentation Yes
Year 2025
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