UROP Research Mentor Project Submission Portal: Submission #1302
Submission information
              Submission Number: 1302
  Submission ID: 21106
  Submission UUID: 861b6577-ef7d-41d5-8533-c2722219269c
      Submission URI: /urop-research-mentor-project-submission-portal
          Submission Update: /urop-research-mentor-project-submission-portal?token=2QQ40QdgFMg_Ssa1GVkGNt9wj2m4T5dhtpS_8CRo_tI
      Created: Wed, 08/20/2025 - 06:12 PM
  Completed: Wed, 08/20/2025 - 06:12 PM
  Changed: Tue, 09/23/2025 - 05:43 PM
  Remote IP address: 144.174.212.88
  Submitted by: Anonymous
  Language: English
  Is draft: No
    Webform: UROP Project Proposal Portal
      Submitted to: UROP Research Mentor Project Submission Portal
    
          Research Mentor Information
      
  
  
  Kislay Parvatiyar
  
  
  
  
      
  
  
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  Dr.
  
  
  
  
  
      
  
  
  Faculty
  
  
  
  
      
  
  
  Education, Health, and Human Sciences
  
  
  
  
      
  
  
  Health, Nutrition, and Food Sciences
  
  
  
  
      
  
  
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          Overall Project Details
      
  
  
  Investigating the innate immune response to bacterial quorum sensing molecules
  
  
  
  
      
  
  
  innate immunity; pattern recognition receptors; host defense
  
  
  
  
      
  
  
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  2
  
  
  
  
      
  
  
  Biological sciences, Biochemistry, Health Sciences, etc
  
  
  
  
      
  
  
  On FSU Main Campus
  
  
  
  
      
  
  
  Project is on FSU main campus
  
  
  
  
      
  
  
  In-person
  
  
  
  
      
  
  
  9-10
  
  
  
  
      
  
  
  Flexible schedule (Combination of business and outside of business. TBD between student and research mentor.)
  
  
  
  
      
  
  
  Understanding how pathogen associated molecular patterns (PAMPs) modulate the host innate immune response provides important insight into infectious disease pathogenesis and other chronic inflammatory conditions. The bacterial molecule N-(3-oxo-dodecanoyl)-L-homoserine lactone (C12) is produced by the opportunistic pathogen Pseudomonas aeruginosa and has been well characterized for its role in quorum sensing and regulation of bacterial metabolism and motility. Its effects on host immunity are not well understood.
Our preliminary data implicates C12 as a mediator of mitochondrial dysfunction in multiple cell types. We observed that C12 can induce the expression of type-I interferons in mammalian macrophage cells. This induction is apparently dependent on STING, a critical signaling component of the cytosolic DNA sensing pathway. We will attempt to further characterize the mechanisms by which C12 activates type-I interferons in a STING dependent manner.
  Our preliminary data implicates C12 as a mediator of mitochondrial dysfunction in multiple cell types. We observed that C12 can induce the expression of type-I interferons in mammalian macrophage cells. This induction is apparently dependent on STING, a critical signaling component of the cytosolic DNA sensing pathway. We will attempt to further characterize the mechanisms by which C12 activates type-I interferons in a STING dependent manner.
      
  
  
  Biochemical and immunological benchwork including cell culture, quantitative real-time PCR, SDS PAGE, immunoblot, data analysis.
  
  
  
  
      
  
  
  Ideal applicants will have successfully completed an introductory biology and chemistry course.
  
  
  
  
      
  
  
  Teaching and mentorship has always been a rewarding experience throughout my academic career. The cornerstone of my teaching philosophy is that fundamental biological principles must be understood and not memorized, a notion that needs to be instilled in the classroom and in the laboratory. Concepts learned in lectures, seminars and meetings need to be reinforced in small, interactive group activities that include journal clubs, round-table discussions and lab meetings. Furthermore, the process of discovery is as vital to learning science as it is to research. Students who are given the opportunity to make scientific discoveries and contributions are more motivated and engaged, and develop critical thinking skills that are invaluable in scientific research. As a teacher and mentor, I’ve facilitated student learning and discovery through an emphasis on scientific reasoning, group problem solving, and assessing scientific data. I’ve also recognized that not all students learn in the same manner. As such, I’ve utilized one-on-one, personalized approaches to scientific education, focusing on the individual strengths of students to further encourage and develop their scientific endeavors.
  
  
  
  
      
  
  
  https://pubmed.ncbi.nlm.nih.gov/?term=parvatiyar+k&sort=date
  
  
  
  
      
  
  
  Please reach out if you have interests in immunology, aging, and/or signal transduction research.
  
  
  
          
      
  
  
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UROP Program Elements
      
  
  
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  2025
  
  
  
  
      
  
  
  https://cre.fsu.edu/urop-research-mentor-project-submission-portal?token=2QQ40QdgFMg_Ssa1GVkGNt9wj2m4T5dhtpS_8CRo_tI