UROP Research Mentor Project Submission Portal: Submission #1302

Submission information
Submission Number: 1302
Submission ID: 21106
Submission UUID: 861b6577-ef7d-41d5-8533-c2722219269c

Created: Wed, 08/20/2025 - 06:12 PM
Completed: Wed, 08/20/2025 - 06:12 PM
Changed: Mon, 08/25/2025 - 11:28 AM

Remote IP address: 144.174.212.88
Submitted by: Anonymous
Language: English

Is draft: No

Research Mentor Information

Kislay Parvatiyar
He/Him
Dr.
kparvatiyar@fsu.edu
Faculty
Education, Health, and Human Sciences
Health, Nutrition, and Food Sciences
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Additional Research Mentor(s)

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Overall Project Details

Investigating the innate immune response to bacterial quorum sensing molecules
innate immunity; pattern recognition receptors; host defense
Yes
2
Biological sciences, Biochemistry, Health Sciences, etc
On FSU Main Campus
Project is on FSU main campus
In-person
9-10
Flexible schedule (Combination of business and outside of business. TBD between student and research mentor.)
Understanding how pathogen associated molecular patterns (PAMPs) modulate the host innate immune response provides important insight into infectious disease pathogenesis and other chronic inflammatory conditions. The bacterial molecule N-(3-oxo-dodecanoyl)-L-homoserine lactone (C12) is produced by the opportunistic pathogen Pseudomonas aeruginosa and has been well characterized for its role in quorum sensing and regulation of bacterial metabolism and motility. Its effects on host immunity are not well understood.
Our preliminary data implicates C12 as a mediator of mitochondrial dysfunction in multiple cell types. We observed that C12 can induce the expression of type-I interferons in mammalian macrophage cells. This induction is apparently dependent on STING, a critical signaling component of the cytosolic DNA sensing pathway. We will attempt to further characterize the mechanisms by which C12 activates type-I interferons in a STING dependent manner.
Biochemical and immunological benchwork including cell culture, quantitative real-time PCR, SDS PAGE, immunoblot, data analysis.
Ideal applicants will have successfully completed an introductory biology and chemistry course.
Teaching and mentorship has always been a rewarding experience throughout my academic career. The cornerstone of my teaching philosophy is that fundamental biological principles must be understood and not memorized, a notion that needs to be instilled in the classroom and in the laboratory. Concepts learned in lectures, seminars and meetings need to be reinforced in small, interactive group activities that include journal clubs, round-table discussions and lab meetings. Furthermore, the process of discovery is as vital to learning science as it is to research. Students who are given the opportunity to make scientific discoveries and contributions are more motivated and engaged, and develop critical thinking skills that are invaluable in scientific research. As a teacher and mentor, I’ve facilitated student learning and discovery through an emphasis on scientific reasoning, group problem solving, and assessing scientific data. I’ve also recognized that not all students learn in the same manner. As such, I’ve utilized one-on-one, personalized approaches to scientific education, focusing on the individual strengths of students to further encourage and develop their scientific endeavors.
Please reach out if you have interests in immunology, aging, and/or signal transduction research.
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UROP Program Elements

Yes
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2025
https://cre.fsu.edu/urop-research-mentor-project-submission-portal?token=2QQ40QdgFMg_Ssa1GVkGNt9wj2m4T5dhtpS_8CRo_tI