UROP Research Mentor Project Submission Portal: Submission #1272

serial: '1272'
sid: '20956'
uuid: 5a546b04-c506-49bc-8fa7-ffcfee833f71
uri: /urop-research-mentor-project-submission-portal
created: '1755557041'
completed: '1755557041'
changed: '1756137089'
in_draft: '0'
current_page: ''
remote_addr: 174.227.244.198
uid: '0'
langcode: en
webform_id: urop_project_proposal_portal
entity_type: node
entity_id: '1116'
locked: '0'
sticky: '0'
notes: ''
metatag: meta
data:
  roundtable_info: {  }
  approximately_how_many_hours_a_week_would_the_research_assistant: '10'
  are_you_currently_looking_for_students_: 'Maybe one more'
  confirmation_1: '1'
  contact_email_fsu_email: ''
  contact_email_fsu_email2: ''
  contact_email_fsu_email_if_affiliated_: db03d@fsu.edu
  faculty_advisor_confirmation: '1'
  faculty_advisor_name: 'Dr. Robert J. Tomko Jr.'
  faculty_advisor_s_fsu_email: robert.tomko@med.fsu.edu
  fsu_college: Medicine
  fsu_department_if_applicable_: 'Biomedical Sciences'
  headshot_optional_: ''
  if_the_project_location_is_off_campus_does_the_student_need_to_p: ''
  mentoring_philosophy: |
    My mentoring philosophy is to pay forward the guidance and knowledge I received, creating a supportive environment for trainees to grow. A strong mentoring relationship, in my view, is built on trust, support, and a gradual transition toward independence.
    I begin by being directly involved, providing answers to establish a sense of psychological safety. As a trainee’s confidence grows, I shift to asking more questions, encouraging them to think critically. My goal is to empower them to become independent thinkers and practitioners. Through this process, I hope to instill a genuine excitement for scientific research, balanced with a respectful skepticism toward existing work. I provide practical knowledge, from technical skills to professional conduct, and teach them how to ask effective questions.
    Beyond specific tasks, I aim to build my trainees' confidence and equip them with essential skills like critical thinking and problem-solving that will serve them throughout their careers. By creating a trusting relationship, discussions can naturally extend to career development and personal growth.
    Ultimately, my goal is to help mentees not only succeed in the present but also to develop the mindset and skills they need for a successful and fulfilling future.
  mentor_handbook_and_faqs: '1'
  name_of_other_faculty_collaborator_if_applicable_: ''
  number_of_assistants_needed_faculty_postdoc_max_6_graduate_stude: '1'
  other_faculty_collaborator_s_preferred_pronouns: ''
  overall_research_project_description: 'The 26S proteasome is an unusually large ATP-dependent self-compartmentalized protease responsible for most intracellular protein degradation in eukaryotes. As the terminal component of the ubiquitin proteasome system, it plays a pivotal role in regulating essential cellular processes, including cell cycle progression and gene expression. Formation of proteasomes requires the precise interactions of ~66 individual proteins that must rapidly assemble in the dense cellular milieu. Efforts to understand the assembly process have thus been inferred from static snapshots of presumed assembly intermediates, leading to the proposal of conflicting assembly pathways and uncertainty regarding the timing and kinetics of the process.  To address this, we have adapted a non-radioactive pulse-chase system to dynamically track subunit incorporation and the localization of assembly events in living cells. The trainee work directly with the graduate research assistant to generate a comprehensive kinetic model of proteasome biogenesis, and help to elucidate WHERE in the cell these assembly steps occur. This innovative integrated and quantitative approach will provide new insights into assembly of multi-subunit complexes in general, and will inform efforts to prevent or reverse proteasome insufficiency in human diseases. Importantly, this knowledge can be impactful to a host of human diseases associated with dysregulated homeostasis, including cancer, musculoskeletal diseases, and neurodegenerative diseases.'
  please_add_any_additional_information_here: ''
  please_provide_a_link_to_your_publications_a_video_clip_or_a_web: ''
  please_select_the_choice_that_most_accurately_describes_your_exp: In-person
  please_select_the_location_of_your_project_: 'On FSU Main Campus'
  position_availability_for_student_research: 'Flexible schedule'
  position_title: 'Graduate Student'
  primary_research_mentor_name: 'Daniel Betancourt'
  project_keywords: 'multi-subunit complex assembly, molecular kinetics, fluorescence microscopy'
  relevant_student_major_s_: 'Biochemistry, bioengineering, biology, '
  research_mentor_preferred_pronoun2: ''
  research_mentor_pronouns: ''
  research_mentor_supervisor_if_different_from_above_: ''
  research_tasks_for_student_research_assistant_s_: 'The student will be required to assist in various tasks in the laboratory and virtually. In the lab, the student will be assisting with steps in preparation and of analytical gels (SDS PAGE), sample preparation, assist with yeast cultures, mount samples to microscope slides and stain for immunofluorescence microscopy, fluorescence microscopy analysis, image processing for localization analysis'
  roundtable_times_and_zoom_links: ''
  skills_that_research_assistants_may_need_: 'Attention to detail, ability to follow directions and repeat tasks from protocols or self-prepared notes, ability to adapt to shifting priorities '
  title_of_the_project: 'Unraveling the Temporal and Spatial Regulation of Proteasome Biogenesis'
  update_url: 'https://cre.fsu.edu/urop-research-mentor-project-submission-portal?token=rjMe8e7foT3y00L3tvE6CKV1i2SxhFEt6rH8zLzTuJU'
  urop_performance_evaluation: '1'
  urop_poster_presentation: '1'
  when_potential_research_assistants_are_reaching_out_via_email_2: ''
  when_potential_research_assistants_are_reaching_out_via_email_wh: ''
  when_students_are_reaching_out_via_email_what_is_your_preferreda: ''
  would_you_like_to_participate_in_the_urop_research_mentor_round2: 'No'
  would_you_like_to_participate_in_the_urop_research_mentor_roundt: 'No'
  year: '2025'