UROP Research Mentor Project Submission Portal: Submission #1013

Research Mentor Information
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Primary Research Mentor Name: Yan Li
Research Mentor Preferred Pronouns: Dr. Li
When potential research assistants are reaching out via email, what is your preferred honorific?: Dr.
Contact Email (FSU Email if affiliated): yli@eng.famu.fsu.edu
Position Title: Faculty
FSU College (if applicable): FAMU-FSU College of Engineering
FSU Department or Non-FSU Organization Affiliation: Florida State University
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Additional Research Mentor(s)
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Research Assistant Supervisor (if different from above): Colin Esmonde
Research Assistant Supervisor Preferred Pronouns: {Empty}
Research Assistant Supervisor Preferred Honorific?: {Empty}
Contact Email (FSU Email if affiliated): cme18b@fsu.edu
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Other Faculty/Collaborator(s) Preferred Honorific?: {Empty}
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Overall Project Details
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Title of the Project: Chimeric antigen receptor engineered extracellular vesicle delivery for treating neurological disorders
Project Keywords: extracellular vesicles, human stem cells, 3-D culture, neural engineering
Are you currently looking for research assistants?: No
Number of Research Assistants Needed : 1
Relevant Research Assistant Major(s):
Biomedical Engineering

Project Location:: 2525 Pottsdamer St., Tallahassee, FL
If the project location is off campus, does the research assistant(s) need to provide their own transportation?: Yes
Please select the choice that most accurately describes your expectations for the research assistant(s):: Partially Remote
Approximately how many hours a week would the research assistant(s) need to work?: 5-10
Roughly what time frame do you expect research assistant(s) to work?: During business hours
Overall Research Project Description:
Immune therapy has proven to be an effective method of targeting FAP overexpressing cells for lysis, especially in cancer research. By using engineered chimeric antigen receptors (CARs), patient immune cells can be programmed to target tumor and tumor- associated antigens, eliciting a strong inflammatory response that is difficult for tumors to suppress. T-cells engineered to express CARs that target FAP localize to the tumor microenvironment, destroying fibroblasts in the tumor stroma that mediate immune suppression and cause tumor- associated fibrosis.

Research Tasks:
 literature review, data collection, data analysis,

Skills that research assistant(s) may need::
cell culture, reading and writing skills, 

Mentoring Philosophy:
I mainly focus on the self-motivation driven research. I will identify the students' motivation and motivate them more. I help and encourage students to pay attention to small details and put deep thoughts while performing experiments.  When students gain more understanding and skills, I challenge them to develop independent thoughts.   I also share my own experience. I create a safe environment in which mentees feel that is acceptable to fail and learn from their mistakes. 

Please provide a link to your publications, a video clip, or a website for your research project (if applicable):: https://scholar.google.com/citations?user=hHCTRMgAAAAJ&hl=en
Please add any additional information here (if applicable)::
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Are you interested in participating in the UROP Research Mentor Roundtable?: Yes
Roundtable times and Zoom links:
Sep 03, 2:00pm-2:30pm
Join Zoom Meeting 
https://fsu.zoom.us/j/92174327545 
Meeting ID: 921 7432 7545 


Roundtable Info:
- Day: Wednesday, September 3
  Start Time: 2:00
  End Time: 2:30
  Zoom Link: https://fsu.zoom.us/j/92174327545  Meeting ID: 921 7432 7545 

UROP Program Elements
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Mentor Handbook, FAQs, and Communication: Yes
UROP Performance Evaluation: Yes
Materials Grant: Yes
UROP Poster Presentation: Yes

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Year: 2025
update url: https://cre.fsu.edu/urop-research-mentor-project-submission-portal?token=3pN6_h1prrWJYTGWnXNgZW1F8rtRpBTdFHNQkRflP3g