UROP Research Mentor Project Submission Portal: Submission #681

serial: '681'
sid: '14026'
uuid: 4ac91c63-d173-49f5-908f-2fedbe53f2e2
uri: /urop-research-mentor-project-submission-portal
created: '1721155438'
completed: '1721155438'
changed: '1728305124'
in_draft: '0'
current_page: ''
remote_addr: 128.186.173.128
uid: '0'
langcode: en
webform_id: urop_project_proposal_portal
entity_type: node
entity_id: '1116'
locked: '0'
sticky: '0'
notes: ''
metatag: meta
data:
  roundtable_info: {  }
  approximately_how_many_hours_a_week_would_the_research_assistant: '3'
  are_you_currently_looking_for_students_: 'No'
  confirmation_1: '1'
  contact_email_fsu_email: ''
  contact_email_fsu_email2: ''
  contact_email_fsu_email_if_affiliated_: ts21m@fsu.edu
  faculty_advisor_confirmation: '1'
  faculty_advisor_name: 'Timothy Megraw, PhD'
  faculty_advisor_s_fsu_email: timothy.megraw@med.fsu.edu
  fsu_college: Medicine
  fsu_department_if_applicable_: 'FSU Department'
  headshot_optional_: ''
  if_the_project_location_is_off_campus_does_the_student_need_to_p: ''
  mentoring_philosophy: 'My mentoring philosophy centers on fostering curiosity, critical thinking, and resilience in aspiring scientists. I aim to create a supportive environment where mentees feel empowered to explore, innovate, and learn from failures. By sharing my expertise and encouraging collaboration, I strive to inspire the next generation of scientific leaders.'
  mentor_handbook_and_faqs: '1'
  name_of_other_faculty_collaborator_if_applicable_: ''
  number_of_assistants_needed_faculty_postdoc_max_6_graduate_stude: '1'
  other_faculty_collaborator_s_preferred_pronouns: ''
  overall_research_project_description: |
    The epidemic outbreak of the Zika virus (ZIKV) in 2015 from Asia and Africa to the Americas raised serious health concerns worldwide due to its association with neurological disorders. ZIKV is a mosquito-transmitted flavivirus that encodes three virus structural proteins and seven non-structural (NS) proteins involved in virus replication, packaging and host manipulation. ZIKV replicates its genome in the cytosol and assembles virus particles in a virus-regulated compartment called the replication factory or viroplasm in part by remodeling the endoplasmic reticulum. I show that one of the ZIKV proteins, NS3, is sufficient to assemble a viroplasm-like structure (VLS) that organizes microtubules in human cells. NS3 is a multidomain protein containing protease and helicase domains. I will describe how similar the VLS is to the ZIKV-induced viroplasm and describe the molecular mechanisms by which NS3 forms VLS. Overall, these discoveries improve our grasp of how viruses hijack cells for replication and offer potential routes for protecting humans against infections.
  please_add_any_additional_information_here: ''
  please_provide_a_link_to_your_publications_a_video_clip_or_a_web: 'https://www.youtube.com/watch?v=5tadvTZDyh4&t=59s'
  please_select_the_choice_that_most_accurately_describes_your_exp: In-person
  please_select_the_location_of_your_project_: 'On FSU Main Campus'
  position_availability_for_student_research: 'Flexible schedule'
  position_title: 'Graduate Student'
  primary_research_mentor_name: 'Tania Sultana'
  project_keywords: 'Zika Virus, ZIKV, Flavivirus, Microcephaly, NS3, Replication Factory, VLS'
  relevant_student_major_s_: 'Biology is preferred but not limited to.'
  research_mentor_preferred_pronoun2: ''
  research_mentor_pronouns: ''
  research_mentor_supervisor_if_different_from_above_: ''
  research_tasks_for_student_research_assistant_s_: 'literature review, Confocal Imaging, data analysis or may include writing'
  roundtable_times_and_zoom_links: ''
  skills_that_research_assistants_may_need_: 'Just willing to learn '
  title_of_the_project: 'Zika virus NS3 drives the assembly of a viroplasm-like structure'
  update_url: 'https://cre.fsu.edu/urop-research-mentor-project-submission-portal?token=NfHWO3DsDQs-G6QxnSUwrii-BJR1vQieyJZ_6pVDLo4'
  urop_performance_evaluation: '1'
  urop_poster_presentation: '1'
  when_potential_research_assistants_are_reaching_out_via_email_2: ''
  when_potential_research_assistants_are_reaching_out_via_email_wh: ''
  when_students_are_reaching_out_via_email_what_is_your_preferreda: ts21m@fsu.edu
  would_you_like_to_participate_in_the_urop_research_mentor_round2: 'No'
  would_you_like_to_participate_in_the_urop_research_mentor_roundt: ''
  year: '2024'