UROP Research Mentor Project Submission Portal: Submission #681 | Center for Undergraduate Research and Academic Engagement

Submission information

Submission Number: 681

Submission ID: 14026

Submission UUID: 4ac91c63-d173-49f5-908f-2fedbe53f2e2

Submission URI: /urop-research-mentor-project-submission-portal

Submission Update: /urop-research-mentor-project-submission-portal?token=NfHWO3DsDQs-G6QxnSUwrii-BJR1vQieyJZ_6pVDLo4

Created: Tue, 07/16/2024 - 02:43 PM

Completed: Tue, 07/16/2024 - 02:43 PM

Changed: Mon, 10/07/2024 - 08:45 AM

Remote IP address: 128.186.173.128

Submitted by: Anonymous

Language: English

Is draft: No

Webform: UROP Project Proposal Portal

Submitted to: UROP Research Mentor Project Submission Portal

Research Mentor Information

Primary Research Mentor Name Tania Sultana

Research Mentor Preferred Pronouns {Empty}

When potential research assistants are reaching out via email, what is your preferred honorific? ts21m@fsu.edu

Contact Email (FSU Email if affiliated) ts21m@fsu.edu

Position Title Graduate Student

Faculty Advisor Name Timothy Megraw, PhD

Faculty Advisor's FSU Email timothy.megraw@med.fsu.edu

FSU College (if applicable) Medicine

FSU Department or Non-FSU Organization Affiliation FSU Department

Headshot (optional) {Empty}

Additional Research Mentor(s)

Research Assistant Supervisor (if different from above) {Empty}

Research Assistant Supervisor Preferred Pronouns {Empty}

Research Assistant Supervisor Preferred Honorific? {Empty}

Contact Email (FSU Email if affiliated) {Empty}

Name of Other Faculty/Collaborator(s) (if applicable) {Empty}

Other Faculty/Collaborator(s) Preferred Pronouns {Empty}

Other Faculty/Collaborator(s) Preferred Honorific? {Empty}

Contact Email (FSU Email if affiliated) {Empty}

Overall Project Details

Title of the Project Zika virus NS3 drives the assembly of a viroplasm-like structure

Project Keywords Zika Virus, ZIKV, Flavivirus, Microcephaly, NS3, Replication Factory, VLS

Are you currently looking for research assistants? No

Number of Research Assistants Needed 1

Relevant Research Assistant Major(s) Biology is preferred but not limited to.

Project Location: On FSU Main Campus

If the project location is off campus, does the research assistant(s) need to provide their own transportation? {Empty}

Please select the choice that most accurately describes your expectations for the research assistant(s): In-person

Approximately how many hours a week would the research assistant(s) need to work? 3

Roughly what time frame do you expect research assistant(s) to work? Flexible schedule (Combination of business and outside of business. TBD between student and research mentor.)

Overall Research Project Description The epidemic outbreak of the Zika virus (ZIKV) in 2015 from Asia and Africa to the Americas raised serious health concerns worldwide due to its association with neurological disorders. ZIKV is a mosquito-transmitted flavivirus that encodes three virus structural proteins and seven non-structural (NS) proteins involved in virus replication, packaging and host manipulation. ZIKV replicates its genome in the cytosol and assembles virus particles in a virus-regulated compartment called the replication factory or viroplasm in part by remodeling the endoplasmic reticulum. I show that one of the ZIKV proteins, NS3, is sufficient to assemble a viroplasm-like structure (VLS) that organizes microtubules in human cells. NS3 is a multidomain protein containing protease and helicase domains. I will describe how similar the VLS is to the ZIKV-induced viroplasm and describe the molecular mechanisms by which NS3 forms VLS. Overall, these discoveries improve our grasp of how viruses hijack cells for replication and offer potential routes for protecting humans against infections.

Research Tasks literature review, Confocal Imaging, data analysis or may include writing

Skills that research assistant(s) may need: Just willing to learn

Mentoring Philosophy My mentoring philosophy centers on fostering curiosity, critical thinking, and resilience in aspiring scientists. I aim to create a supportive environment where mentees feel empowered to explore, innovate, and learn from failures. By sharing my expertise and encouraging collaboration, I strive to inspire the next generation of scientific leaders.

Please provide a link to your publications, a video clip, or a website for your research project (if applicable): https://www.youtube.com/watch?v=5tadvTZDyh4&t=59s

Please add any additional information here (if applicable): {Empty}

Are you interested in participating in the UROP Research Mentor Roundtable? No

Roundtable times and Zoom links {Empty}

UROP Program Elements

Mentor Handbook, FAQs, and Communication Yes

UROP Performance Evaluation Yes

Materials Grant Yes

UROP Poster Presentation Yes

Faculty Advisor Confirmation Yes

Are you interested in attending in a UROP Research Mentor Workshop Series? {Empty}

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Year 2024

update url https://cre.fsu.edu/urop-research-mentor-project-submission-portal?token=NfHWO3DsDQs-G6QxnSUwrii-BJR1vQieyJZ_6pVDLo4