BIO

My name is Joseph Liberato, I am a first generation immigrant from Colombia and a first generation student as well. I lived in Vero Beach before attending Florida State University. My goal is to work in Space health and medicine after I graduate.

Long-term Effects of Simulated Spaceflight Exposure to the Mesenteric Artery

Abstract

The digestive, or gastrointestinal (GI), system includes the small and large intestines, though our knowledge of GI adaptations from spaceflight exposure is limited. The spaceflight environment subjects astronauts to extreme conditions such as temperature variations, deep-space radiation, and microgravity, and restricted diets. This environment predisposes crew to increased risk of developing medical conditions. To assess these risks and how they may affect the digestive system, we conducted a study of the long-term single and combined effects of simulated deep-space radiation and microgravity exposure on rats. We investigate blood vessel structure of arteries (e.g. mesenteric artery) that supply blood to the digestive system. Biological samples of the mesenteric arteries were collected from rats and are being further processed by cryostat sectioning to conduct immunofluorescence protein analysis for the following markers: eNOS, CD31, and SM22A markers. Indeed as more people travel into space, we have much to discover about the effects of space flight on the cardiovascular system, in particular as we return to the Moon through our Artemis Program. The findings from this study will increase our overall knowledge in the field of space medicine and life sciences as well as improve life on Earth through advancements made in medicine and health.

Keywords: NASA, Physiology, Digestive System, Mesenteric artery, cardiovascular system