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uri: /urop-research-mentor-project-submission-portal
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webform_id: urop_project_proposal_portal
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data:
  approximately_how_many_hours_a_week_would_the_research_assistant: '6'
  are_you_currently_looking_for_students_: 'Yes'
  confirmation_1: '1'
  contact_email_fsu_email: ''
  contact_email_fsu_email2: ''
  contact_email_fsu_email_if_affiliated_: rschurko@fsu.edu
  fsu_college: 'Arts and Sciences'
  fsu_department_if_applicable_: 'Chemistry and National High Magnetic Field Laboratory'
  headshot_optional_: ''
  if_the_project_location_is_off_campus_does_the_student_need_to_p: ''
  mentoring_philosophy: 'The best way for a student to figure out if they are interested in research is to actively get involved in cutting edge research programs.  Undergraduate students in my research group will be trained in technical skills (NMR, X-ray diffraction, mechanochemical synthesis) and other research related skills (literature reviews, data analysis, presenting/writing about their research) under the direct supervision of myself and a senior Ph.D. graduate student.  We will provide desk space, research training, and access to some of the best people and instrumentation associated with NMR spectroscopy in the world.'
  mentor_handbook_and_faqs: '1'
  name_of_other_faculty_collaborator_if_applicable_: ''
  number_of_assistants_needed_faculty_postdoc_max_6_graduate_stude: '1'
  other_faculty_collaborator_s_preferred_pronouns: ''
  overall_research_project_description: |
    Synopsis
    	An undergraduate project is available for students in chemistry or physics that are interested in the use of ultra-high magnetic field nuclear magnetic resonance (NMR) spectroscopy to characterize solid forms of active pharmaceutical ingredients (APIs). Required background: undergraduate chemistry or physics students, completed 2 years of study minimum.  Locations: NMR spectroscopy at MagLab; Synthesis, X-ray, Computation at FSU

    Experience and benefits to the student
    	Undergraduate researchers will learn techniques in solid-state mechanochemical synthesis (ball milling and related solid-state methods), multinuclear solid-state NMR (SSNMR) spectroscopy (1H, 2H, 13C, 14N, 15N, 17O, 23Na, 35Cl, and others), powder X-ray diffraction (pXRD), and basic quantum computational methods like density functional theory (DFT) as applied to NMR crystallography.  This introductory research project will provide strong grounding in solid-state chemistry and/or physics, with a flexible set of project options available.

    Project details
    	Most drug products, or active pharmaceutical ingredients (APIs), are synthesized, manufactured as dosage forms, stored, and ingested as solid materials.  Of these, the majority are formulated as hydrochloride (HCl) salts, for purposes of increasing solubility, stability, and bioavailability.  Numerous structural forms of the same drug, known as polymorphs, can have markedly different properties, and also represent unique intellectual property.  Furthermore, new solid forms, produced as multi-component crystals, are currently of great interest in the pharmaceutical and crystal engineering communities, due to the possibility of tuning the materials to have desirable pharmaceutical properties. Paramount to the successful crystal engineering is our ability to characterize molecular level structure, and also to predict molecular structure using spectroscopic, diffraction, and computational methods.  Undergraduate researchers will work under the supervision of the PI and senior graduate students/post-docs on this project.

    	In the proposed undergraduate research project, mechanochemical ball milling will be used to synthesize an array of multi-component cocrystals that involve HCl salts of several APIs and pharmaceutically acceptable coformers.  Careful consideration in the crystal engineering of these systems will be undertaken.  Starting reagents and final products will be characterized with SSNMR and pXRD.  This experimental data will be used in a plane-wave DFT framework to solve the crystal structures of these systems.  Aspects of this work will involve collaborations with other scientists from around the world, and several major pharmaceutical companies. 
  please_add_any_additional_information_here: ''
  please_provide_a_link_to_your_publications_a_video_clip_or_a_web: 'https://www.chem.fsu.edu/~schurko/'
  please_select_the_choice_that_most_accurately_describes_your_exp: In-person
  please_select_the_location_of_your_project_: 'On FSU Main Campus'
  position_availability_for_student_research: 'During Business Hours'
  position_title: Faculty
  primary_research_mentor_name: 'Robert Schurko'
  project_keywords: 'pharmaceuticals, NMR, drug products, solid state chemistry'
  relevant_student_major_s_: 'Chemistry, Biochemistry, Physics'
  research_mentor_preferred_pronoun2: ''
  research_mentor_pronouns: he/him
  research_mentor_supervisor_if_different_from_above_: ''
  research_tasks_for_student_research_assistant_s_: |
    literature review, data collection, data analysis, conducting interviews, etc. 
    synthesis of cocrystals of drugs, solid-state NMR spectroscopy, basic instrumental analysis techniques, data analysis, literature review
  roundtable_times_and_zoom_links: ''
  skills_that_research_assistants_may_need_: |
    Required background: undergraduate chemistry, biochemistry, or physics students, completed 2 years of study minimum.  
    No experience in NMR is necessary; students will be trained
  title_of_the_project: 'Mechanochemical Synthesis of Co-crystals of Drug Products and their Characterization with Ultra-High Field Solid-State NMR Spectroscopy'
  update_url: 'https://cre.fsu.edu/urop-research-mentor-project-submission-portal?token=93Hgte6gHpMdFKQvZUtai0d1oBTTh8x-7vPrVLgOtqU'
  urop_performance_evaluation: '1'
  urop_poster_presentation: '1'
  when_potential_research_assistants_are_reaching_out_via_email_2: ''
  when_potential_research_assistants_are_reaching_out_via_email_wh: ''
  when_students_are_reaching_out_via_email_what_is_your_preferreda: Prof.
  would_you_like_to_participate_in_the_urop_research_mentor_roundt: ''
  year: '2023'