UROP Research Mentor Project Submission Portal: Submission #845

serial: '845'
sid: '14851'
uuid: 00a415ee-17d1-43ef-bbc2-3c92104cf8dd
uri: /urop-research-mentor-project-submission-portal
created: '1724004229'
completed: '1724004229'
changed: '1726746124'
in_draft: '0'
current_page: ''
remote_addr: 128.186.171.48
uid: '0'
langcode: en
webform_id: urop_project_proposal_portal
entity_type: node
entity_id: '1116'
locked: '0'
sticky: '0'
notes: ''
metatag: meta
data:
  roundtable_info: {  }
  approximately_how_many_hours_a_week_would_the_research_assistant: 'Minimum of 5-10 hours per week'
  are_you_currently_looking_for_students_: 'No'
  confirmation_1: '1'
  contact_email_fsu_email: ''
  contact_email_fsu_email2: ''
  contact_email_fsu_email_if_affiliated_: antonia.nemec@med.fsu.edu
  faculty_advisor_confirmation: ''
  faculty_advisor_name: ''
  faculty_advisor_s_fsu_email: ''
  fsu_college: Medicine
  fsu_department_if_applicable_: 'Biomedical Sciences'
  headshot_optional_: ''
  if_the_project_location_is_off_campus_does_the_student_need_to_p: ''
  mentoring_philosophy: 'I believe that mentors are continually growing and adapting to their educational environment. Mentors need to be open to different situations and flexible in order to adjust to meet the needs of students. Understanding my own strengths and weaknesses and always being open to criticism and improvement is crucial to be a great mentor.  l take advantage of workshops that are available and continue my own education in order to keep up to date on the literature in my field. More importantly, I believe that continuing with my education keeps my research up-to-date, exciting, and inspirational to my students. Ultimately, my goal is to provide students with the tools to succeed and push them to reach their potential.  '
  mentor_handbook_and_faqs: '1'
  name_of_other_faculty_collaborator_if_applicable_: 'Robb Tomko'
  number_of_assistants_needed_faculty_postdoc_max_6_graduate_stude: '1'
  other_faculty_collaborator_s_preferred_pronouns: he/him/his
  overall_research_project_description: 'Microsporidia are a family of spore-forming obligate intracellular parasites that infect most animals, including humans. Microsporidia are a pathogen of increasing health interest to humans. Although they typically only infect people with compromised immune systems, the widespread prescribing of immunosuppressants for diverse human conditions (i.e., autoimmune diseases) is resulting in a recent uptick in the number of human cases of microsporidiosis. Despite this growing threat from microsporidia, there are currently zero FDA-approved treatments for these parasites. Our group is interested in studying the highly unusual proteasome of microsporidia, as a potential drug target for treatment of microsporidiosis. The proteasome, a large, complex multi-subunit protease, is responsible for the degradation of unwanted or unneeded proteins and maintains protein homeostasis in all eukaryotic cells. The proteasome is a validated drug target and there are several FDA-approved drugs used as chemotherapies. Microsporidia have a highly divergent proteasome (m26S) and may be distinct enough that it can be targeted with a drug that would not have an appreciable effect on the human proteasome. At present, there is no high-resolution structural information of the m26S. In this project, we will begin studies into one of the three sub-complexes of the m26S, the mBase, the sub-complex that contains the ATPases that unfold the proteins as they are fed into the chamber of the proteasome for degradation. Any differences between the m26S and the human 26S can serve as potential targets for treatment of microsporidiosis.'
  please_add_any_additional_information_here: ''
  please_provide_a_link_to_your_publications_a_video_clip_or_a_web: 'https://med.fsu.edu/tomkoLab/research '
  please_select_the_choice_that_most_accurately_describes_your_exp: In-person
  please_select_the_location_of_your_project_: 'On FSU Main Campus'
  position_availability_for_student_research: 'During Business Hours'
  position_title: Faculty
  primary_research_mentor_name: 'Antonia Nemec'
  project_keywords: 'proteasome, microsporidia, proteolysis, ATPase, drug target'
  relevant_student_major_s_: 'Biochemistry, Chemistry, Interdisciplinary Medical Sciences (IMS)'
  research_mentor_preferred_pronoun2: ''
  research_mentor_pronouns: she/her/hers
  research_mentor_supervisor_if_different_from_above_: ''
  research_tasks_for_student_research_assistant_s_: 'Molecular cloning, recombinant protein expression and purification; standard yeast genetic and cell work'
  roundtable_times_and_zoom_links: ''
  skills_that_research_assistants_may_need_: 'Any lab experience is recommended for sophomores. This would include lab courses within the undergraduate curriculum (i.e., CHM1045L, CHM1046L, etc.). Freshmen would not be expected any lab experience. '
  title_of_the_project: 'Dissecting proteasome biogenesis in microsporidia'
  update_url: 'https://cre.fsu.edu/urop-research-mentor-project-submission-portal?token=sdGuS50j6PIbWL-8RUvqREVYydm8DzlkGS0DhD1OMD8'
  urop_performance_evaluation: '1'
  urop_poster_presentation: '1'
  when_potential_research_assistants_are_reaching_out_via_email_2: ''
  when_potential_research_assistants_are_reaching_out_via_email_wh: Dr.
  when_students_are_reaching_out_via_email_what_is_your_preferreda: Dr.
  would_you_like_to_participate_in_the_urop_research_mentor_round2: 'No'
  would_you_like_to_participate_in_the_urop_research_mentor_roundt: ''
  year: '2024'