UROP Research Mentor Project Submission Portal: Submission #798

serial: '798'
sid: '14616'
uuid: 155cccad-da32-406e-818f-c185a8e993d4
uri: /urop-research-mentor-project-submission-portal
created: '1723739279'
completed: '1724090402'
changed: '1724689903'
in_draft: '0'
current_page: ''
remote_addr: 144.174.212.120
uid: '0'
langcode: en
webform_id: urop_project_proposal_portal
entity_type: node
entity_id: '1116'
locked: '0'
sticky: '0'
notes: ''
metatag: meta
data:
  roundtable_info: {  }
  approximately_how_many_hours_a_week_would_the_research_assistant: '5-10 hrs'
  are_you_currently_looking_for_students_: 'Yes'
  confirmation_1: '1'
  contact_email_fsu_email: vogunkunle2@fsu.edu
  contact_email_fsu_email2: ''
  contact_email_fsu_email_if_affiliated_: sa20ep@fsu.edu
  faculty_advisor_confirmation: '1'
  faculty_advisor_name: 'Robert Silvers'
  faculty_advisor_s_fsu_email: rsilvers@fsu.edu
  fsu_college: 'Arts and Sciences'
  fsu_department_if_applicable_: 'Institute of Molecular Biophysics'
  headshot_optional_: ''
  if_the_project_location_is_off_campus_does_the_student_need_to_p: ''
  mentoring_philosophy: "As a PhD student, I want to mentor an undergraduate research assistant because I believe in the value of collaborative learning and the profound impact it can have on both the mentor and mentee. Guiding an undergraduate student through the research process allows me to share the knowledge and skills I've gained over the years, fostering their growth, confidence, and passion for the field. Mentoring also challenges me to refine my leadership and communication abilities, as I translate complex concepts into accessible ideas and adapt my teaching style to suit the needs of the student. Moreover, working with an enthusiastic undergraduate brings fresh perspectives and new energy to my research, potentially leading to innovative ideas and approaches. I see this experience as an opportunity to contribute meaningfully to the academic community by nurturing the next generation of scholars, helping them build a strong foundation for their future academic and professional endeavors."
  mentor_handbook_and_faqs: '1'
  name_of_other_faculty_collaborator_if_applicable_: ''
  number_of_assistants_needed_faculty_postdoc_max_6_graduate_stude: '2'
  other_faculty_collaborator_s_preferred_pronouns: ''
  overall_research_project_description: |-
    Our lab is focused in understanding the interaction between La-Related Proteins (LARPs) with RNA. LARPs proteins are found to have implication in different sort of diseases like cancer and so on. We, primarily, focus on the biophysical techniques to decipher the underlying the biochemistry of these RNA binding proteins. Eventually, we aim to structurally characterize these interactions using Nuclear Magnetic Resonance experiments. 
    Specifically, in this project,  we would study LARP1 (La-Related Protein 1)  which is an RNA-binding protein that is primarily involved in the translation and stability of mRNAs. Human LARP1(Hs LARP1) is found to play a role in post-translation regulation of 5’ terminal oligopyrimidine motif (5’ TOP), a cis-regulatory RNA component of the 7-methylguanosine cap of TOP mRNAs. The La-module of HsLARP1 has been shown to bind with 5’TOP and 3’ poly(A) motifs of mRNA compared to other LARPs. As LARP1 has been found to repress TOP mRNA translation via the C-terminal DM15 region, the role of the N-terminal La-Module in the regulation of TOP mRNAs is still ambiguous. Since it has been known that LaMOD in HsLARP1 has a folded LaM domain followed by an intrinsically unstructured region (IUR). Here, we investigate the dynamics of the unstructured region of human LARP1 along with its effects on the activity of La-module. We devised the constructs to express and purify IUR regions of humans LARP1 using a self-cleaving peptide N-pro EDDIE to study the RNA-binding mechanism followed by structure characterization using NMR experiments.
  please_add_any_additional_information_here: ''
  please_provide_a_link_to_your_publications_a_video_clip_or_a_web: ''
  please_select_the_choice_that_most_accurately_describes_your_exp: In-person
  please_select_the_location_of_your_project_: 'On FSU Main Campus'
  position_availability_for_student_research: 'During Business Hours'
  position_title: 'Graduate Student'
  primary_research_mentor_name: 'Shibu Adhikari'
  project_keywords: 'RNA, NMR, LARPs'
  relevant_student_major_s_: |-
    Chemistry
    Biochemistry
    Biology
    ** Anyone with basic knowledge of general chemistry and biochemistry.
  research_mentor_preferred_pronoun2: ''
  research_mentor_pronouns: ''
  research_mentor_supervisor_if_different_from_above_: 'Victoria Ogunkunle'
  research_tasks_for_student_research_assistant_s_: |-
    Literature Review
    Setting Up Experiments
    Data Collection
    Scientific Writing 
  roundtable_times_and_zoom_links: ''
  skills_that_research_assistants_may_need_: |-
    Recommended:
    Pipetting Techniques

    ** As a wet lab biochemistry research lab, skills will be trained along the way. One should be motivated to learn new techniques along with some background information on the particular experiment.
  title_of_the_project: 'Understanding the molecular interaction between RNA and La-Related Proteins using NMR.'
  update_url: 'https://cre.fsu.edu/urop-research-mentor-project-submission-portal?token=5v1Gvv_aIqPYw4sR9YyIvUJ_d5HGFzX5R4VDQnrq2Xs'
  urop_performance_evaluation: '1'
  urop_poster_presentation: '1'
  when_potential_research_assistants_are_reaching_out_via_email_2: ''
  when_potential_research_assistants_are_reaching_out_via_email_wh: ''
  when_students_are_reaching_out_via_email_what_is_your_preferreda: ''
  would_you_like_to_participate_in_the_urop_research_mentor_round2: 'No'
  would_you_like_to_participate_in_the_urop_research_mentor_roundt: ''
  year: '2024'