UROP Project

The role of SUMOylation in cell cycle

Investigate how SUMOylation of DNA damage repair proteins facilitates damage repair and maintain genome stability, a key mechanism preventing cancer development.

Research Mentor: Yanchang Wang,
Department, College, Affiliation: Biomedical Sciences, Medicine
Contact Email: yanchang.wang@med.fsu.edu
Research Assistant Supervisor (if different from mentor): Sophia Owutey
Research Assistant Supervisor Email:
Faculty Collaborators:
Faculty Collaborators Email:

Looking for Research Assistants: Maybe one more
Number of Research Assistants: 1
Relevant Majors: Biology, chemistry.
Project Location: On FSU Main Campus
Research Assistant Transportation Required:
Remote or In-person: In-person
Approximate Weekly Hours: 10, During business hours
Roundtable Times and Zoom Link:
Not participating in the roundtable

Project Description

DNA damage repair is essential to maintain genome stability and prevent cancer development. SUMOylation is a posttranslational modification, and many DNA damage repair proteins are SUMOylated. However, the function of this protein modification in DNA damage repair remains unclear. This project will use molecular, genetic, and imaging methods to understand how SUMOylation controls the localization of DNA damage repair proteins at damage sites to facilitate damage repair. Results from this project will reveal new mechanisms to maintain genome stability.

Research Tasks: yeast strain construction, imaging with fluorescence microscope, protein analysis using western blotting, media preparation.

Skills that research assistant(s) may need: recommended: basic background knowledge in cell biology and genetics.