UROP Project

Chimeric antigen receptor engineered extracellular vesicle delivery for treating neurological disorders

extracellular vesicles, human stem cells, 3-D culture, neural engineering

Research Mentor: Dr. Yan Li, Dr. Li
Department, College, Affiliation: Florida State University, FAMU-FSU College of Engineering
Contact Email: yli@eng.famu.fsu.edu
Research Assistant Supervisor (if different from mentor): Colin Esmonde
Research Assistant Supervisor Email: cme18b@fsu.edu
Faculty Collaborators:
Faculty Collaborators Email:

Looking for Research Assistants: Maybe one more
Number of Research Assistants: 1
Relevant Majors: Biomedical Engineering
Project Location: 2525 Pottsdamer St., Tallahassee, FL
Research Assistant Transportation Required: Yes
Remote or In-person: Partially Remote
Approximate Weekly Hours: 5-10, During business hours
Roundtable Times and Zoom Link:

• Day: Wednesday, September 3
  Start Time: 2:00
  End Time: 2:30
  Zoom Link: https://fsu.zoom.us/j/92174327545 Meeting ID: 921 7432 7545

Project Description

Immune therapy has proven to be an effective method of targeting FAP overexpressing cells for lysis, especially in cancer research. By using engineered chimeric antigen receptors (CARs), patient immune cells can be programmed to target tumor and tumor- associated antigens, eliciting a strong inflammatory response that is difficult for tumors to suppress. T-cells engineered to express CARs that target FAP localize to the tumor microenvironment, destroying fibroblasts in the tumor stroma that mediate immune suppression and cause tumor- associated fibrosis.

Research Tasks: literature review, data collection, data analysis,

Skills that research assistant(s) may need: cell culture, reading and writing skills,