Research Symposium
23rd annual Undergraduate Research Symposium, April 6, 2023
Rafael Tkachenko Poster Session 1: 11:00 am - 12:00 pm/ Poster #264
BIO
I was born in Caracas, Venezuela and I moved to the united states when I was seven years old. I always enjoyed studying science especially biology that's why my research interest is Biomedical sciences. I am aspiring to be a physician in the future.
Rat coronary poster
Authors: Rafael Tkachenko, S. Anand NarayananStudent Major: Biology
Mentor: S. Anand Narayanan
Mentor's Department: Research Faculty Mentor's College: College of Health and Human Sciences Co-Presenters: Hanna Neustadter
Abstract
Human travel into space exposes them to the spaceflight environment, which includes extreme temperature variations, exposure to deep-space radiation, and the effects of weightlessness (e.g. microgravity). Physiological adaptations occur when exposed to these different environmental stimuli, increasing the crew's risk of developing medical conditions. Some of these risks include cardiovascular adaptations, musculoskeletal deconditioning, and spaceflight-associated neuro-ocular syndrome. To assess these risks and how they may affect the cardiovascular system, we conducted a study of the long-term single and combined effects of deep space radiation and microgravity exposure on rats. Our hypothesis includes studying changes in blood vessel structure and function, as well as biochemical pathway changes (e.g. endothelial nitric oxide synthase [eNOS], oxidative stress) resulting from simulated spaceflight exposure. Rat coronary arteries were collected and processed by cryostat sectioning to assess changes in protein pathways through immunofluorescence. Findings from this study will increase our overall knowledge in the field of space medicine and life sciences, as well as improve life on Earth through advancements made in medicine and health.
Keywords: Space Medicine Cardiovascular Biochemical