BIO

My name is Kaitlyn Ritt and I am a freshman at Florida State University from Tampa, Florida. I am majoring in exercise physiology on a pre-dental track and I am so excited to present the research that I have assisted with this year!

Creatine Monohydrate Supplementation Improves Microvascular Blood Flow But Not Glucose Homeostasis in Response To A Meal

Abstract

Chronic hyperglycemia can lead to several health conditions, such as type 2 diabetes and cardiovascular disease. The harmful effects of hyperglycemia are mainly due to the elevation of oxidative stress in the form of reactive oxygen species (ROS), which can negatively impact cellular function and overall health. Previous studies have used indirect surrogates to assess oxidative stress; however, a novel microdialysis technique was used in this study to measure in-vivo production of ROS. Methods: A pre-post study design was implemented to determine if five days of 20 grams of CM supplementation could reduce the risk factors associated with endothelial dysfunction at rest and in response to a high carbohydrate or fat bolus in a range of individuals. Results: There was a significant increase in ROS concentrations after consuming a high carbohydrate or fat bolus post CM supplementation compared to pre. However, one participant with obesity displayed significant reductions in ROS concentrations post CM supplementation. Baseline and peak interstitial glucose were not different after CM supplementation than pre-CM supplementation. Conclusion: The findings suggest that CM supplementation may serve as a potent intervention to reduce ROS concentrations in a diseased population but not a healthy population.

Keywords: Creatine, Microvascular, Glucose