Research Symposium

BIO

Hello! I’m Gannon Walcot, a sophomore from Schuylkill Haven, PA, currently majoring in Interdisciplinary Medical Sciences with a focus on Clinical Professions. I have aspirations of attending medical school and specializing in Cardiology. My research interests lie within the healthcare field, particularly focusing on the cardiovascular system, as well as nutrition and its impact on health. I’m dedicated to advancing medical knowledge and look forward to contributing to the field through both my academic journey and future career.

Effects of Parental Permethrin Exposure on Fetal and Offspring Obesity Development

Abstract

This study explored the impact of a parental diet consisting of permethrin, an insecticide, or corn oil on lipid accumulation in offspring mice. 10-week-old female and male mice were administered high-fat diets (HFD) supplemented with either permethrin or corn oil during mating, pregnancy, and lactation. After weaning (3 weeks), both male and female offspring’s lipid panels, body weight, and weight of white adipose tissue (eWAT)
accumulation were recorded. Permethrin exposure significantly increased body weight, eWAT, triglycerides (TG), and insulin in both male and female offspring. Contrastingly, permethrin exposure had no effect on fasting blood glucose and total cholesterol (TC) for
either male or female offspring. Interestingly, male offspring exposed to permethrin experienced a decrease in high-density lipoprotein cholesterol and an increase in lowdensity lipoprotein cholesterol while females who were exposed were unaffected. These
results suggest underlying sex differences in metabolic responses to permethrin and uncover the obesogenic potential of permethrin exposure during fetal and offspring development.

Keywords: Effects of Permethrin on Offspring