BIO

My name is Matthew Hutchins, I am originally from Titusville, Florida. Currently I serve as a researcher here at FSU with a passion for cell and tissue engineering. I'm constantly drawn to the forefront of scientific innovation, eager to channel my expertise into the pharmaceutical industry and revolutionize human medicine. My commitment to advancing biotechnological solutions reflects my ambition to leave a lasting impact on global health.

Developing An AI-based Particle-tracking Algorithm For Cardiac Muscle Cell Growth and Contractility

Abstract

Our goal is to evaluate images showing the assembly and disassembly processes, which will be important examples for constructing an algorithm to estimate sarcomere growth within cardiac muscle cells. Reaching this objective will make a substantial contribution to our knowledge of the dynamics of the heart muscle and may also yield new perspectives on exercise physiology and heart health. The study of sarcomere growth in real time may yield important insights into the heart's response to different stimuli, which could guide the creation of effective treatments for cardiovascular disorders. Furthermore, this approach might be used more broadly to investigate the cellular dynamics of other muscle tissues, which would promote tissue engineering and regenerative medicine. This multidisciplinary approach has the potential to spur innovation and advancement in the field of biomedical research and lead to groundbreaking discoveries. The expansion of each individual cardiac muscle cell propels the heart's growth in response to exercise. Sarcomere construction, the cytoskeletal framework seen in muscle cells, facilitates this expansion. Our team has the ability to stimulate cells to work harder in a lab setting, which causes the cells to spontaneously boost the creation of sarcomeres. A crucial protein found in sarcomeres, alpha-actinin acts as a structural element that makes it easier for other proteins, such as actin, to be anchored. In a recent paper, we demonstrated the ability of two medications to control sarcomere construction and disassembly. So far, we've used specialized dyes to visualize sarcomeres and immobilized heart muscle cells to track this progress.

Keywords: Sacromere, AI, Cells, Matlab, Heart