BIO

My name is Mia De Sabatino and I am from Fort Lauderdale, Florida. Currently, I am a junior at Florida State University studying chemistry and have been active in my research lab for a year. Research has always been a focus because there is no better way to utilize what you have learned in real-life applications. It is a great way to evolve your understanding and develop new skills that can help prepare for graduate school. After graduating from Florida State University, I hope to attend graduate school and continue to pursue research in electrochemistry. It has become an exciting interest as I continue to further understand my role in this field.

Investigating the Effect of Toyocamycin on A549 Cells

Abstract

Adenocarcinoma is a common cancer of the lung, and the discovery of new anticancer drugs effective against lung cancer will open up new therapeutic opportunities such as combination therapy. Toyocamycin is an antibiotic that has shown effect on cancer cells such as multiple myeloma and pancreatic cancer cells. By using scanning ion conductance microscopy (SICM), Toyocamycin is found effective against adenocarcinoma cells such as A549. The drug induced membrane blebbing, cell shrinkage, and apoptotic volume decrease. This technique is suitable in continuous mapping of the topography of single cells before and after treatment with anticancer drugs, as a result of its label free and non-invasive nature. Toyocamycin is effective against A549 cells, and other biochemical assays could be used to further confirm the effect of the drug.

Keywords: cell morphology, drug studies, electrochemistry