UROP Research Mentor Project Submission Portal: Submission #555

Submission information
Submission Number: 555
Submission ID: 9046
Submission UUID: 27525ef8-857c-4518-8d5b-e924a40de6a8

Created: Wed, 08/23/2023 - 11:39 AM
Completed: Thu, 08/24/2023 - 05:13 PM
Changed: Thu, 10/05/2023 - 10:05 AM

Remote IP address: 69.254.161.249
Submitted by: Anonymous
Language: English

Is draft: No

Research Mentor Information

Caroline Menton
She/Her
Ms.
cbm20bv@med.fsu.edu
Graduate Student
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Medicine
Florida State University College of Medicine
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Additional Research Mentor(s)

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Overall Project Details

The Effects of Caffeine on Motor Performance in Parkinson's Disease
Caffeine, Neurodegenerative Disease, Parkinson's Disease
No
1
Neuroscience, biology, chemistry, pre-med, IMS
On FSU Main Campus
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Partially Remote
5
Flexible schedule (Combination of business and outside of business. TBD between student and research mentor.)
The purpose of this study is to acquire data on the gross and fine motor function of patients with Parkinson’s Disease when they are at peak dose of primary therapy and compare this with data collected at peak dose with a caffeine adjuvant of ~3mg/kg. The treatment standard for PD is dopamine replacement therapy (e.g. levodopa) to improve quality of life and reduce falls risk. Over time, patients may require increasing dose and frequency of levodopa therapy, which can precipitate side effects (e.g. dyskinesia) and hasten the rate of disease progression. To prevent this, researchers have been investigating adjuvants and supplements that can improve peak performance on levodopa. While the neuroprotective effects of caffeine are well established in the literature, the acute effects of caffeine on motor performance have not been sufficiently evaluated. In this study, we will examine the acute effects of caffeine as an adjuvant therapy during peak dose of primary therapy in Parkinson’s patients. Detailed analysis of the physical effects of caffeine is necessary to determine what, if any, role caffeine can play in the treatment and management of PD. This study is a double-blinded crossover study using randomized placebo-intervention to assess the effect of caffeine on motor performance.
Literature review, Data Analysis, write-up
Recommend - statistics
My goal is for this to be a meaningful experience for everyone involved. I am hoping to share my enthusiasm for this project (and for research in general), and to work together to make something awesome! This is a great opportunity for students to learn about clinical research, and I want to create an environment that encourages students to become proficient researchers and creative thinkers.
You can view the IRB for this project on the RAMP IRB page (STUDY00001144). Feel free to email me with additional questions.

UROP Program Elements

Yes
Yes
Yes
Yes
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No
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2023
https://cre.fsu.edu/urop-research-mentor-project-submission-portal?token=iqw5ogqTP2aAoxBcDroGUz3kPjQ9kZJfecGyB7r13_w