UROP Research Mentor Project Submission Portal: Submission #408
Submission information
Submission Number: 408
Submission ID: 8311
Submission UUID: 924ee44f-44b2-4719-a877-782766ae627b
Submission URI: /urop-research-mentor-project-submission-portal
Submission Update: /urop-research-mentor-project-submission-portal?token=0se7ap1NlOYg97tXNVTztwYiGp0g80DjgFtt2BZuG9I
Created: Thu, 08/10/2023 - 04:28 PM
Completed: Thu, 08/10/2023 - 04:28 PM
Changed: Fri, 09/01/2023 - 01:37 PM
Remote IP address: 128.186.168.104
Submitted by: Anonymous
Language: English
Is draft: No
Webform: UROP Project Proposal Portal
Submitted to: UROP Research Mentor Project Submission Portal
Research Mentor Information
Additional Research Mentor(s)
Nikita Zalenski
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Turner Seay
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Overall Project Details
Mechanistic investigation of the Inhibitory mechanisms of a novel blockbuster anti-AIDS drug
HIV. nucleoside analog drug, drug inhibitory mechanism, AIDS
Yes
3
The potential undergraduate researchers should major in biochemistry, biology, chemistry, or biomedical engineering.
On FSU Main Campus
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In-person
8 hours
During business hours
Human Immunodeficiency Virus (HIV) persists as one of the top ten leading causes of death in certain populations. One significant feature of HIV is its ability to mutate with high frequency, garnering resistance to many historical and current anti-HIV medications. Our research aims to investigate the kinetics of the novel nucleoside reverse transcriptase inhibitor (NRTI), Islatravir, with HIV reverse transcriptase (RT) mutants or human DNA polymerases. Islatravir is undergoing multiple phase II and III clinical trials by Merck, Inc. Our research efforts will help Merck to understand the inhibitory mechanism and potential toxicity of Islatravir at molecular level.
bench work, data collection and analysis, and prepare simple project report under the guidance of graduate students and Dr. Suo.
Recommended skills: biochemistry and some chemistry skills, and good bench performance.
As a professor for more than 22 years, I enjoy working with the motivated students. I feel really good when I see my young trainees growing intellectually and professionally. During my career, I have trained about undergraduate researchers in my labs at the Ohio State University and here. The general pattern is that the GPAs of my undergraduate researchers were/are higher after working in my labs.
https://med.fsu.edu/suolab/home
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UROP Program Elements
Yes
Yes
Yes
Yes
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2023
https://cre.fsu.edu/urop-research-mentor-project-submission-portal?token=0se7ap1NlOYg97tXNVTztwYiGp0g80DjgFtt2BZuG9I